Indications for Use EpiFLOSD has FDA clearance to provide safe and effective Transdermal Sustained Oxygen Therapy [TSOT]for the treatment of: Skin ulcerations due to diabetes, venous stasis, post-surgical infections and gangrenous lesions   Decubitus Ulcers (bedsores, pressure sores)   Amputations and infected stumps   Skin grafts   Burns   Frostbite Contraindications The EpiFLOSD system is contraindicated for the following: Inadequate perfusion to support healing   Ulcers due to acute thrombophlebitis;   Ulcers due to Reynaud's disease;   Wounds completely covered with eschar; Wounds with fistulae or deep sinus tracts where the end cannot be probed;   Wounds covered with petroleum-based dressings;   Non-compliant patients.   Clinicians should refer to the instruction sheet provided with the product for all indications, contraindications and warnings.